Evidence That Productive Human Immunodeficiency Virus 3 Type 1 Assembly Can Occur in an Intracellular 4 Compartment 5 6 7
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Matrix mediates the functional link between human immunodeficiency virus type 1 RNA nuclear export elements and the assembly competency of Gag in murine cells.
Human immunodeficiency virus type 1 (HIV-1) assembles poorly in murine cells, reflecting inefficient targeting of the Gag structural polyprotein to the plasma membrane. Virus particle production can be restored by replacing the cis-acting Rev response element (RRE) in Gag-Pol mRNAs with multiple copies of the CTE (4xCTE), suggesting a mechanistic link between HIV-1 RNA trafficking and productiv...
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Fig. 1. Virus. (A) Structure. Simplified scheme of virus structure, with a lipid envelope that can be present or not; a protein-composed capsid and the genetic material, that can be DNA or RNA, double or single strand. (B) Life cycle. Example of the course of adeno-associated virus (AAV) productive infection. Scheme showing the eight steps of AAV transduction of host cells: (1) viral binding to...
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تاریخ انتشار 2009